Sunday, March 15, 2026

Exemestane and Letrozole

  Apologies for the significant delay since my last post on my ongoing treatment. My last post related to ongoing treatment outlined how tamoxifen was not as kind of a medicine as it had started out to be. Due to this, I was switched to one of three aromatase inhibitors - exemestane. Exemestane is different from Anastrozole or Letrozole (the other two) in that it is a steroidal aromatase inhibitor. This time, it only took about 1 month and it was determined that the side effects of severe anxiety and insomnia would not be side effects I can live with for the next 9 years. Once again, I was taken off the medication and had to wait 1 month to trial another. Enter Letrozole.

 I chose Letrozole because a family member had to use this in the past for 5 years and reported very minimal to no side effects. I figured it may be kind to me as well and so far, just over one month in, it's the lesser of all evils I've tried to date. I feel less fatigue and joint pain than when I was on Tamoxifen and no insomnia or anxiety like I felt with Exemestane. I'm experiencing minimal joint pain that I'm managing with naproxen. I'm also having some brain fog with word finding difficulties and short term forgetfulness, but I just do my best and move on. I'm hoping I've found the best one for me!




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